Yes! You can change the orientation of the PDF you create with the PDF Designer. The default orientation is portrait, but you can change it to landscape. This might be helpful if you have large tables that do not fit in portrait mode.
Your entire PDF can either be in portrait or landscape mode. You cannot make one page portrait and another page landscape.
To change this setting, visit the Global Settings menu. It is the very first option at the top. Just click the icon to toggle it between Portrait and Landscape.